TargetMol

Myrtucommulone

Product Code:
 
TAR-T28123
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
Myrtucommulone is an inhibitor of the chaperonin activity of HSP60, correlating to LRP130 and LONP aggregation.
CAS:
54247-21-1
Formula:
C38H52O10
Molecular Weight:
668.824
Purity:
0.98
SMILES:
CC(C)[C@@H](C1=C(O)C(C)(C)C(=O)C(C)(C)C1=O)c1c(O)c([C@@H](C(C)C)C2=C(O)C(C)(C)C(=O)C(C)(C)C2=O)c(O)c(C(=O)C(C)C)c1O

References

1. Wiechmann K, M?ller H, K?nig S, Wielsch N, Svato? A, Jauch J, Werz O. Mitochondrial Chaperonin HSP60 Is the Apoptosis-Related Target for Myrtucommulone. Cell Chem Biol. 2017 Apr 27. pii: S2451-9456(17)30108-3. doi: 10.1016/j.chembiol.2017.04.008. [Epub ahead of print] PubMed PMID: 28457707. 2. Liu C, Ang S, Huang XJ, Tian HY, Deng YY, Zhang DM, Wang Y, Ye WC, Wang L. Meroterpenoids with New Skeletons from Myrtus communis and Structure Revision of Myrtucommulone K. Org Lett. 2016 Aug 19;18(16):4004-7. doi: 10.1021/acs.orglett.6b01817. Epub 2016 Jul 29. PubMed PMID: 27471772. 3. Izgi K, Iskender B, Sakalar C, Arslanhan A, Y?ksek EH, Hizar E, Canatan H. Effects of Epirubicin and Cisplatin against 4T1 Breast Cancer Cells are Enhanced by Myrtucommulone-A. Anticancer Agents Med Chem. 2016 Apr 4. [Epub ahead of print] PubMed PMID: 27039926. 4. Iskender B, Izgi K, Canatan H. Novel anti-cancer agent myrtucommulone-A and thymoquinone abrogate epithelial-mesenchymal transition in cancer cells mainly through the inhibition of PI3K/AKT signalling axis. Mol Cell Biochem. 2016 May;416(1-2):71-84. doi: 10.1007/s11010-016-2697-y. Epub 2016 Mar 31. PubMed PMID: 27032769.