TargetMol

LY-368975

Product Code:
 
TAR-T27948
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27948-5mg5mg£1,010.00
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TAR-T27948-50mg50mg£1,982.00
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Quantity:
TAR-T27948-100mg100mg£2,560.00
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This product comes from: United States.
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Further Information

Bioactivity:
LY-368975 is a potent and selective inhibitor of the norepinephrine (NE) reuptake site. LY-368975 reduces food consumption in rodents.
CAS:
163059-33-4
Formula:
C17H21NOS
Molecular Weight:
287.42
Purity:
0.98
SMILES:
CNCC[C@H](Oc1ccccc1SC)c1ccccc1

References

1. Filannino MA, Matarrese M, Turolla EA, Masiello V, Moresco RM, Todde S, Verza E, Magni F, Cattaneo A, Bachi A, Kienle MG, Fazio F. Synthesis and carbon-11 labeling of (R)- and (S)-thionisoxetine, norepinephrine reuptake inhibitors, potential radioligands for positron emission tomography. Appl Radiat Isot. 2007 Nov;65(11):1232-9. Epub 2007 Jun 26. PubMed PMID: 17646106. 2. Jones CK, Eastwood BJ, Need AB, Shannon HE. Analgesic effects of serotonergic, noradrenergic or dual reuptake inhibitors in the carrageenan test in rats: evidence for synergism between serotonergic and noradrenergic reuptake inhibition. Neuropharmacology. 2006 Dec;51(7-8):1172-80. Epub 2006 Oct 11. PubMed PMID: 17045620. 3. Iyengar S, Webster AA, Hemrick-Luecke SK, Xu JY, Simmons RM. Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats. J Pharmacol Exp Ther. 2004 Nov;311(2):576-84. Epub 2004 Jul 13. PubMed PMID: 15254142. 4. Katofiasc MA, Nissen J, Audia JE, Thor KB. Comparison of the effects of serotonin selective, norepinephrine selective, and dual serotonin and norepinephrine reuptake inhibitors on lower urinary tract function in cats. Life Sci. 2002 Aug 2;71(11):1227-36. PubMed PMID: 12106588.