TargetMol

LY-329146

Product Code:
 
TAR-T27946
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27946-5mg5mg£930.00
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TAR-T27946-50mg50mg£1,821.00
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Quantity:
TAR-T27946-100mg100mg£2,319.00
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This product comes from: United States.
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Further Information

Bioactivity:
LY-329146 is a selective estrogen receptor modulator (SERM). LY-329146 prevents doxorubicin resistance in tumor cells expressing multidrug resistance-associated protein (MRP) by inhibiting the binding of MRP substrates to the estrogen receptor.
CAS:
191043-78-4
Formula:
C30H32N2O7S3
Molecular Weight:
628.77
Purity:
0.98
SMILES:
CS(=O)(=O)N(c1ccc(cc1)-c1sc2cc(O)ccc2c1C(=O)c1ccc(OCCN2CCCCC2)cc1)S(C)(=O)=O

References

1. Tawari NR, Bag S, Degani MS. Pharmacophore mapping of a series of pyrrolopyrimidines, indolopyrimidines and their congeners as multidrug-resistance-associated protein (MRP1) modulators. J Mol Model. 2008 Oct;14(10):911-21. doi: 10.1007/s00894-008-0330-z. Epub 2008 Jul 11. PubMed PMID: 18618153. 2. Sun H, Miller DW, Elmquist WF. Effect of probenecid on fluorescein transport in the central nervous system using in vitro and in vivo models. Pharm Res. 2001 Nov;18(11):1542-9. PubMed PMID: 11758761. 3. Norman BH, Dantzig AH, Kroin JS, Law KL, Tabas LB, Shepard RL, Palkowitz AD, Hauser KL, Winter MA, Sluka JP, Starling JJ. Reversal of resistance in multidrug resistance protein (MRP1)-overexpressing cells by LY329146. Bioorg Med Chem Lett. 1999 Dec 6;9(23):3381-6. PubMed PMID: 10612603.