TargetMol

LY307452

Product Code:
 
TAR-T27942
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27942-5mg5mg£850.00
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TAR-T27942-50mg50mg£1,661.00
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Quantity:
TAR-T27942-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
LY307452 is a selective antagonist of mGluR2/3.
CAS:
174393-13-6
Formula:
C21H25NO4
Molecular Weight:
355.434
Purity:
0.98
SMILES:
N[C@@H](C[C@H](CCCC(c1ccccc1)c1ccccc1)C(O)=O)C(O)=O

References

1. Sung KW, Choi S, Lovinger DM. Activation of group I mGluRs is necessary for induction of long-term depression at striatal synapses. J Neurophysiol. 2001 Nov;86(5):2405-12. PubMed PMID: 11698530. 2. Li XC, Beart PM, Monn JA, Jones NM, Widdop RE. Type I and II metabotropic glutamate receptor agonists and antagonists evoke cardiovascular effects after intrathecal administration in conscious rats. Br J Pharmacol. 1999 Oct;128(3):823-9. PubMed PMID: 10516668; PubMed Central PMCID: PMC1571690. 3. Dutar P, Vu HM, Perkel DJ. Pharmacological characterization of an unusual mGluR-evoked neuronal hyperpolarization mediated by activation of GIRK channels. Neuropharmacology. 1999 Apr;38(4):467-75. PubMed PMID: 10221750. 4. Jones NM, Monn JA, Beart PM. Type I and II metabotropic glutamate receptors regulate the outflow of [3H]D-aspartate and [14C]gamma-aminobutyric acid in rat solitary nucleus. Eur J Pharmacol. 1998 Jul 17;353(1):43-51. PubMed PMID: 9721038.