TargetMol

LSN2463359

Product Code:
 
TAR-T27854
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27854-1mg1mg£98.00
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TAR-T27854-5mg5mg£135.00
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TAR-T27854-1mL1 mL * 10 mM (in DMSO)£142.00
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TAR-T27854-10mg10mg£174.00
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TAR-T27854-25mg25mg£303.00
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Quantity:
TAR-T27854-50mg50mg£436.00
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Quantity:
TAR-T27854-100mg100mg£610.00
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Quantity:
TAR-T27854-500mg500mg£1,219.00
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Quantity:
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This product comes from: United States.
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Further Information

Bioactivity:
LSN2463359 is a positive allosteric modulators of the mGlu? receptor.
CAS:
1401031-52-4
Formula:
C16H15N3O
Molecular Weight:
265.316
Pathway:
Neuroscience
Purity:
0.98
SMILES:
CC(C)NC(=O)c1ccc(cn1)C#Cc1ccncc1
Target:
GluR

References

1. Gilmour G, Broad LM, Wafford KA, Britton T, Colvin EM, Fivush A, Gastambide F, Getman B, Heinz BA, McCarthy AP, Prieto L, Shanks E, Smith JW, Taboada L, Edgar DM, Tricklebank MD. In vitro characterisation of the novel positive allosteric modulators of the mGlu? receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat. Neuropharmacology. 2013 Jan;64:224-39. doi: 10.1016/j.neuropharm.2012.07.030. PubMed PMID: 22884720. 2. Gastambide F, Gilmour G, Robbins TW, Tricklebank MD. The mGlu? positive allosteric modulator LSN2463359 differentially modulates motor, instrumental and cognitive effects of NMDA receptor antagonists in the rat. Neuropharmacology. 2013 Jan;64:240-7. doi: 10.1016/j.neuropharm.2012.07.039. PubMed PMID: 22884612. 3. Gastambide F, Cotel MC, Gilmour G, O'Neill MJ, Robbins TW, Tricklebank MD. Selective remediation of reversal learning deficits in the neurodevelopmental MAM model of schizophrenia by a novel mGlu5 positive allosteric modulator. Neuropsychopharmacology. 2012 Mar;37(4):1057-66. doi: 10.1038/npp.2011.298. PubMed PMID: 22129780; PubMed Central PMCID: PMC3280638.