TargetMol

Lecozotan HCl

Product Code:
 
TAR-T27806
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T27806-1mg1mg£201.00
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TAR-T27806-5mg5mg£384.00
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TAR-T27806-10mg10mg£544.00
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TAR-T27806-25mg25mg£828.00
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TAR-T27806-50mg50mg£1,099.00
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TAR-T27806-100mg100mg£1,460.00
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TAR-T27806-500mg500mg£2,850.00
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Further Information

Bioactivity:
Lecozotan is a potent and selective 5-HT antagonist. Lecozotan (SRA-333) enhances the stimulated release of glutamate and acetylcholine in the hippocampus and possesses cognitive-enhancing properties. Lecozotan significantly potentiated the potassium chloride-stimulated release of glutamate and acetylcholine in the dentate gyrus of the hippocampus. Chronic administration of lecozotan did not induce 5-HT(1A) receptor tolerance or desensitization in a behavioral model indicative of 5-HT(1A) receptor function. Acute lecozotan administration increases learning and memory in rats without affecting anxiety or behavioral depression.
CAS:
433282-68-9
Formula:
C28H30ClN5O3
Molecular Weight:
520.03
Pathway:
Neuroscience|GPCR/G Protein
Purity:
0.98
SMILES:
Cl.C[C@H](CN(C(=O)c1ccc(cc1)C#N)c1ccccn1)N1CCN(CC1)c1cccc2OCCOc12
Target:
5-HT Receptor

References

1. Parks V, Philipp AW, Raje S, Plotka A, Schechter LE, Connell J, Chalon S. Concomitant blockade of 5-HT(1A) receptor and 5-HT transporter: use of the Hunter Serotonin toxicity criteria in a clinical pharmacology study. Eur Neuropsychopharmacol. 2012 Feb;22(2):92-9. doi: 10.1016/j.euroneuro.2011.06.002. PubMed PMID: 21733663. 2. Skirzewski M, Hernandez L, Schechter LE, Rada P. Acute lecozotan administration increases learning and memory in rats without affecting anxiety or behavioral depression. Pharmacol Biochem Behav. 2010 May;95(3):325-30. doi: 10.1016/j.pbb.2010.02.008. PubMed PMID: 20170670. 3. Sabbagh MN. Drug development for Alzheimer's disease: where are we now and where are we headed? Am J Geriatr Pharmacother. 2009 Jun;7(3):167-85. doi: 10.1016/j.amjopharm.2009.06.003. Review. PubMed PMID: 19616185; PubMed Central PMCID: PMC2948028. 4. Patat A, Parks V, Raje S, Plotka A, Chassard D, Le Coz F. Safety, tolerability, pharmacokinetics and pharmacodynamics of ascending single and multiple doses of lecozotan in healthy young and elderly subjects. Br J Clin Pharmacol. 2009 Mar;67(3):299-308. doi: 10.1111/j.1365-2125.2008.03348.x. PubMed PMID: 19523013; PubMed Central PMCID: PMC2675040.