TargetMol

LB80317

Product Code:
 
TAR-T27801
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27801-5mg5mgEnquire
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Further Information

Bioactivity:
LB-80317, a DNA polymerase inhibitor, is used potentially for the potential treatment of hepatitis B virus infection.
CAS:
441785-24-6
Formula:
C10H14N5O5P
Molecular Weight:
315.226
Purity:
0.98
SMILES:
Nc1nc2n(CC3(CC3)OCP(O)(O)=O)cnc2c(=O)[nH]1

References

1. Jung JA, Kim SR, Kim TE, Kim JR, Lee SY, Huh W, Ko JW. Pharmacokinetic comparison of the maleate and free base formulations of LB80380, a novel nucleotide analog, in healthy male volunteers. Int J Clin Pharmacol Ther. 2012 Sep;50(9):657-64. PubMed PMID: 22981147. 2. Yuen MF, Lee SH, Kang HM, Kim CR, Kim J, Ngai V, Lai CL. Pharmacokinetics of LB80331 and LB80317 following oral administration of LB80380, a new antiviral agent for chronic hepatitis B (CHB), in healthy adult subjects, CHB patients, and mice. Antimicrob Agents Chemother. 2009 May;53(5):1779-85. doi: 10.1128/AAC.01290-08. Epub 2009 Feb 17. PubMed PMID: 19223649; PubMed Central PMCID: PMC2681521. 3. Yuen MF, Kim J, Kim CR, Ngai V, Yuen JC, Min C, Kang HM, Shin BS, Yoo SD, Lai CL. A randomized placebo-controlled, dose-finding study of oral LB80380 in HBeAg-positive patients with chronic hepatitis B. Antivir Ther. 2006;11(8):977-83. PubMed PMID: 17302367.