TargetMol

KRP-109

Product Code:
 
TAR-T27747
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27747-5mg5mg£1,171.00
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TAR-T27747-50mg50mg£2,303.00
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Quantity:
TAR-T27747-100mg100mg£3,042.00
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This product comes from: United States.
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Further Information

Bioactivity:
KRP-109, a neutrophil elastase (NE) inhibitor, acts by decreasing expression of TGF-? Signal Related Genes.
CAS:
1275996-50-3
Formula:
C26H30N4O7
Molecular Weight:
510.547
Purity:
0.98
SMILES:
OC(=O)C=C/C(O)=O.CCc1cc(OC)cc2nc(oc(=O)c12)-c1cccnc1N1CCC(C1)N(C)C

References

1. Chillappagari S, M?ller C, Mahavadi P, Guenther A, N?hrlich L, Rosenblum J, Rubin BK, Henke MO. A small molecule neutrophil elastase inhibitor, KRP-109, inhibits cystic fibrosis mucin degradation. J Cyst Fibros. 2016 May;15(3):325-31. doi: 10.1016/j.jcf.2015.10.008. Epub 2015 Oct 30. PubMed PMID: 26526358. 2. Yamada K, Yanagihara K, Araki N, Harada Y, Morinaga Y, Izumikawa K, Kakeya H, Yamamoto Y, Hasegawa H, Kohno S, Kamihira S. In vivo efficacy of KRP-109, a novel elastase inhibitor, in a murine model of severe pneumococcal pneumonia. Pulm Pharmacol Ther. 2011 Dec;24(6):660-5. doi: 10.1016/j.pupt.2011.08.001. Epub 2011 Aug 16. PubMed PMID: 21864700.