TargetMol

JNJ-2408068

Product Code:
 
TAR-T27668
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27668-5mg5mg£377.00
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TAR-T27668-50mg50mg£1,661.00
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Quantity:
TAR-T27668-100mg100mg£2,079.00
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Further Information

Bioactivity:
JNJ-2408068 is an inhibitor of respiratory syncytial virus (RSV). JNJ-2408068 exhibited potent antiviral activity with EC50 of 2.1 nM. A similar inhibitory effect was observed in a RSV-mediated cell fusion assay (EC50= 0.9 nM). JNJ-2408068 interferes with RSV fusion through a mechanism involving a similar interaction with the F protein.
CAS:
317846-22-3
Formula:
C22H30N6O
Molecular Weight:
394.523
Purity:
0.98
SMILES:
Cc1ccc(O)c(Cn2c(NC3CCN(CCN)CC3)nc3c(C)cccc23)n1

References

1. Del Vecchio AM, Sarisky RT. Cold virus fusion or stopping fusion cold--inhibitors of the human respiratory syncytial virus F protein. Recent Pat Antiinfect Drug Discov. 2006 Jun;1(2):247-54. Review. PubMed PMID: 18221150. 2. Bonfanti JF, Doublet F, Fortin J, Lacrampe J, Guillemont J, Muller P, Queguiner L, Arnoult E, Gevers T, Janssens P, Szel H, Willebrords R, Timmerman P, Wuyts K, Janssens F, Sommen C, Wigerinck P, Andries K. Selection of a respiratory syncytial virus fusion inhibitor clinical candidate, part 1: improving the pharmacokinetic profile using the structure-property relationship. J Med Chem. 2007 Sep 20;50(19):4572-84. Epub 2007 Aug 28. PubMed PMID: 17722899. 3. Douglas JL, Panis ML, Ho E, Lin KY, Krawczyk SH, Grant DM, Cai R, Swaminathan S, Chen X, Cihlar T. Small molecules VP-14637 and JNJ-2408068 inhibit respiratory syncytial virus fusion by similar mechanisms. Antimicrob Agents Chemother. 2005 Jun;49(6):2460-6. PubMed PMID: 15917547; PubMed Central PMCID: PMC1140497. 4. Wyde PR, Chetty SN, Timmerman P, Gilbert BE, Andries K. Short duration aerosols of JNJ 2408068 (R170591) administered prophylactically or therapeutically protect cotton rats from experimental respiratory syncytial virus infection. Antiviral Res. 2003 Nov;60(3):221-31. PubMed PMID: 14638398.