TargetMol

GGTI2417

Product Code:
 
TAR-T27412
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27412-5mg5mg£1,010.00
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TAR-T27412-50mg50mg£1,982.00
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Quantity:
TAR-T27412-100mg100mg£2,560.00
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This product comes from: United States.
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Further Information

Bioactivity:
GGTI2417 is a potent and selective inhibitor of Geranylgeranyltransferase I. GGTI2417 targets RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth.
CAS:
501010-05-5
Formula:
C24H33N5O4
Molecular Weight:
455.559
Purity:
0.98
SMILES:
COC(=O)[C@H](CC(C)C)NC(=O)N1CCN(Cc2nc[nH]c2C)C(=O)[C@@H]1Cc1ccccc1

References

1. Kazi A, Carie A, Blaskovich MA, Bucher C, Thai V, Moulder S, Peng H, Carrico D, Pusateri E, Pledger WJ, Berndt N, Hamilton A, Sebti SM. Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy. Mol Cell Biol. 2009 Apr;29(8):2254-63. doi: 10.1128/MCB.01029-08. Epub 2009 Feb 9. PubMed PMID: 19204084; PubMed Central PMCID: PMC2663293. 2. Falsetti SC, Wang DA, Peng H, Carrico D, Cox AD, Der CJ, Hamilton AD, Sebti SM. Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth. Mol Cell Biol. 2007 Nov;27(22):8003-14. Epub 2007 Sep 17. PubMed PMID: 17875936; PubMed Central PMCID: PMC2169159.