TargetMol

FR-194921

Product Code:
 
TAR-T27379
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27379-5mg5mg£850.00
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TAR-T27379-50mg50mg£1,661.00
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Quantity:
TAR-T27379-100mg100mg£2,079.00
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Further Information

Bioactivity:
FR-194921 is a potent, selective, and orally active antagonist for central adenosine A1 receptors with cognitive-enhancing and anxiolytic activity. FR194921 has same binding affinity profile among human, rat, and mouse.
CAS:
202646-80-8
Formula:
C23H23N5O
Molecular Weight:
385.471
Purity:
0.98
SMILES:
CN1CCC(CC1)n1nc(ccc1=O)-c1c(nn2ccccc12)-c1ccccc1

References

1. Matsuya T, Takamatsu H, Murakami Y, Noda A, Ichise R, Awaga Y, Nishimura S. Synthesis and evaluation of [11C]FR194921 as a nonxanthine-type PET tracer for adenosine A1 receptors in the brain. Nucl Med Biol. 2005 Nov;32(8):837-44. PubMed PMID: 16253808. 2. Maemoto T, Tada M, Mihara T, Ueyama N, Matsuoka H, Harada K, Yamaji T, Shirakawa K, Kuroda S, Akahane A, Iwashita A, Matsuoka N, Mutoh S. Pharmacological characterization of FR194921, a new potent, selective, and orally active antagonist for central adenosine A1 receptors. J Pharmacol Sci. 2004 Sep;96(1):42-52. Epub 2004 Sep 4. PubMed PMID: 15351792. 3. Kuroda S, Takamura F, Tenda Y, Itani H, Tomishima Y, Akahane A, Sakane K. Design, synthesis and biological evaluation of a novel series of potent, orally active adenosine A1 receptor antagonists with high blood-brain barrier permeability. Chem Pharm Bull (Tokyo). 2001 Aug;49(8):988-98. PubMed PMID: 11515591.