TargetMol

FR-168888 mesylate

Product Code:
 
TAR-T27372
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27372-5mg5mg£850.00
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TAR-T27372-50mg50mg£1,661.00
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TAR-T27372-100mg100mg£2,079.00
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Further Information

Bioactivity:
FR-168888, a new Na+/H+ exchange inhibitor, can protect the heart from arrhythmia and myocardial cell death in ischemic and reperfused situations.
CAS:
168620-46-0
Formula:
C14H18N4O5S
Molecular Weight:
354.38
Purity:
0.98
SMILES:
CS(O)(=O)=O.NC(=N)NC(=O)c1cc(CO)cc(c1)-n1cccc1

References

1. Zhu BM, Miyamoto S, Kamiya K, Komori S, Hashimoto K. Inhibitory effects of pre-ischemic and post-ischemic treatment with FR 168888, a Na+/H+ exchange inhibitor, on reperfusion-induced ventricular arrhythmias in anesthetized rat. Jpn J Pharmacol. 2002 Jan;88(1):93-9. PubMed PMID: 11855683. 2. Suzuki T, Yamaya M, Sekizawa K, Hosoda M, Yamada N, Ishizuka S, Nakayama K, Yanai M, Numazaki Y, Sasaki H. Bafilomycin A(1) inhibits rhinovirus infection in human airway epithelium: effects on endosome and ICAM-1. Am J Physiol Lung Cell Mol Physiol. 2001 Jun;280(6):L1115-27. PubMed PMID: 11350790. 3. Ohara F, Sugimoto T, Yamamoto N, Ohkubo K, Ozaki T, Maeda K, Seki J, Goto T. Protective effect of FR168888, a new Na+/H+ exchange inhibitor, on ischemia and reperfusion-induced arrhythmia and myocardial infarction in rats: in comparison with other cardioprotective compounds. Jpn J Pharmacol. 1999 Aug;80(4):295-302. PubMed PMID: 10496329.