TargetMol

Ensaculin HCl

Product Code:
 
TAR-T27269
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27269-5mg5mg£850.00
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TAR-T27269-50mg50mg£1,661.00
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TAR-T27269-100mg100mg£2,079.00
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Further Information

Bioactivity:
Ensaculin is a NMDA antagonist and a 5HT1A agonist potentially for the treatment of Alzheimer's disease (AD). Ensaculin showed memory-enhancing effects in paradigms of passive and conditioned avoidance in both normal and artificially amnesic rodents. It exhibited neuroprotective activities in an NMDA toxicity model and neurotrophic effects in primary cultured rat brain cells. In receptor-binding studies, ensaculin was found to have high affinities to serotonergic 5-HT(1A) and 5-HT(7) receptors, adrenergic alpha(1), and dopaminergic D(2) and D(3) receptors.
CAS:
209969-60-8
Formula:
C26H33ClN2O5
Molecular Weight:
489.01
Purity:
0.98
SMILES:
Cl.COc1cc2oc(=O)c(C)c(C)c2cc1OCCCN1CCN(CC1)c1ccccc1OC

References

1. Knauber J, M?ller WE. Anseculin improves passive avoidance learning of aged mice. Pharmacol Res. 2003 Mar;47(3):225-33. PubMed PMID: 12591018. 2. Hoerr R, Noeldner M. Ensaculin (KA-672 HCl): a multitransmitter approach to dementia treatment. CNS Drug Rev. 2002 Summer;8(2):143-58. Review. PubMed PMID: 12177685. 3. Teismann P, Ferger B. Effects of ensaculin on dopamine metabolite levels and K(+)-induced glutamate release. Eur J Pharmacol. 2000 Jun 16;398(2):247-50. PubMed PMID: 10854836. 4. Teismann P, Ferger B. In vivo effects of the putative cognitive enhancer KA-672.HCl in comparison with 8-hydroxy-2-(di-N-propylamino) tetralin and haloperidol on dopamine, 3,4-dihydroxyphenylacetic acid, serotonin and 5-hydroxyindoleacetic acid levels in striatal and cortical brain regions. Prog Neuropsychopharmacol Biol Psychiatry. 2000 Feb;24(2):337-48. PubMed PMID: 10800755.