TargetMol

ELB-139

Product Code:
 
TAR-T27252
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27252-5mg5mg£850.00
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TAR-T27252-50mg50mg£1,661.00
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Quantity:
TAR-T27252-100mg100mg£2,079.00
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Further Information

Bioactivity:
ELB-139 is a GABA A receptor agonist. ELB139 increases 5-HT in the striatum and prefrontal cortex of rats.
CAS:
188116-08-7
Formula:
C14H16ClN3O
Molecular Weight:
277.75
Purity:
0.98
SMILES:
Clc1ccc(cc1)N1CC(=NC1=O)N1CCCCC1

References

1. Landmark CJ, Johannessen SI. Modifications of antiepileptic drugs for improved tolerability and efficacy. Perspect Medicin Chem. 2008 Feb 14;2:21-39. PubMed PMID: 19787095; PubMed Central PMCID: PMC2746576. 2. Langen B, Rundfeldt C. ELB139 an agonist at the benzodiazepine binding site increases 5-HT in the striatum and prefrontal cortex of rats: a microdialysis study. Pharmacol Biochem Behav. 2007 Jan;86(1):79-85. PubMed PMID: 17257662. 3. Rabe H, Kronbach C, Rundfeldt C, L?ddens H. The novel anxiolytic ELB139 displays selectivity to recombinant GABA(A) receptors different from diazepam. Neuropharmacology. 2007 Mar;52(3):796-801. PubMed PMID: 17087982. 4. Grunwald C, Rundfeldt C, Lankau HJ, Arnold T, H?fgen N, Dost R, Egerland U, Hofmann HJ, Unverferth K. Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors. J Med Chem. 2006 Mar 23;49(6):1855-66. PubMed PMID: 16539371.