TargetMol

Donitriptan Mesylate

Product Code:
 
TAR-T27196
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27196-5mg5mg£850.00
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TAR-T27196-50mg50mg£1,661.00
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TAR-T27196-100mg100mg£2,079.00
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Further Information

Bioactivity:
Donitriptan Mesylate, a 5-HT1B/1D agonist, is used potentially for the treatment of migraines.
CAS:
200615-15-2
Formula:
C24H29N5O5S
Molecular Weight:
499.59
Purity:
0.98
SMILES:
CS(O)(=O)=O.NCCc1c[nH]c2ccc(OCC(=O)N3CCN(CC3)c3ccc(cc3)C#N)cc12

References

1. L?tienne R, Blanchet JC, Sole E, John GW, Le Grand B. Donitriptan decreases jugular venous oxygen saturation in rats in the absence of cranial vasoconstriction: an overlooked mechanism of antimigraine action? J Pharmacol Exp Ther. 2005 Nov;315(2):849-57. PubMed PMID: 16027226. 2. Mu?oz-Islas E, Gupta S, Jim?nez-Mena LR, Lozano-Cuenca J, S?nchez-L?pez A, Centuri?n D, Mehrotra S, MaassenVanDenBrink A, Villal?n CM. Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors. Br J Pharmacol. 2006 Sep;149(1):82-91. PubMed PMID: 16880765; PubMed Central PMCID: PMC1629409. 3. Letienne R, Verscheure Y, Perez M, Le Grand B, Colpaert FC, John GW. Donitriptan selectively decreases jugular venous oxygen saturation in the anesthetized pig: further insights into its mechanism of action relevant to headache relief. J Pharmacol Exp Ther. 2003 May;305(2):749-54. PubMed PMID: 12606602. 4. van den Broek RW, MaassenVanDenBrink A, Mulder PG, Bogers AJ, Avezaat CJ, John GW, Saxena PR. Comparison of contractile responses to donitriptan and sumatriptan in the human middle meningeal and coronary arteries. Eur J Pharmacol. 2002 May 17;443(1-3):125-32. PubMed PMID: 12044802.