TargetMol

Diazaborine

Product Code:
 
TAR-T27165
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27165-5mg5mg£850.00
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TAR-T27165-50mg50mg£1,661.00
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Quantity:
TAR-T27165-100mg100mg£2,079.00
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  • Further Information
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Further Information

Bioactivity:
Diazaborine inhibits maturation of rRNAs for the large ribosomal subunit. Diazaborine blocks ribosome biogenesis by inhibiting the AAA-ATPase Drg1. Diazaborine treatment causes, within minutes, a rapid redistribution of the protein from the nucleolus to the periphery of the nucleus, which provides a possible explanation for the effect of diazaborine on rRNA processing.
CAS:
22959-81-5
Formula:
C9H13BN2O3S
Molecular Weight:
272.14
Purity:
0.98
SMILES:
6-methyl-2-(propylsulfonyl)thieno[3,2-d][1,2,3]diazaborinin-1(2H)-ol OB1N(S(=O)(CCC)=O)N=CC2=C1C=C(C)S2

References

1. Bandyopadhyay A, Cambray S, Gao J. Fast Diazaborine Formation of Semicarbazide Enables Facile Labeling of Bacterial Pathogens. J Am Chem Soc. 2017 Jan 18;139(2):871-878. doi: 10.1021/jacs.6b11115. PubMed PMID: 27992180. 2. Ward MS, Silva I, Martinez W, Jefferson J, Rahman S, Garcia JM, Kanichar D, Roppiyakuda L, Kosmowska E, Faust MA, Tran KP, Chow F, Buglo E, Zhou F, Groziak MP, Xu HH. Identification of cellular targets of a series of boron heterocycles using TIPA II-A sensitive target identification platform. Bioorg Med Chem. 2016 Aug 1;24(15):3267-75. doi: 10.1016/j.bmc.2016.05.058. PubMed PMID: 27301675; PubMed Central PMCID: PMC4992540. 3. Jordan CA, Sandoval BA, Serobyan MV, Gilling DH, Groziak MP, Xu HH, Vey JL. Crystallographic insights into the structure-activity relationships of diazaborine enoyl-ACP reductase inhibitors. Acta Crystallogr F Struct Biol Commun. 2015 Dec;71(Pt 12):1521-30. doi: 10.1107/S2053230X15022098. PubMed PMID: 26625295; PubMed Central PMCID: PMC4666481. 4. Kim EJ, Lee JK. Effect of changes in the composition of cellular fatty acids on membrane fluidity of Rhodobacter sphaeroides. J Microbiol Biotechnol. 2015 Feb;25(2):162-73. PubMed PMID: 25418478.