TargetMol

Clociguanil

Product Code:
 
TAR-T27043
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27043-5mg5mg£850.00
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Quantity:
TAR-T27043-50mg50mg£1,661.00
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Quantity:
TAR-T27043-100mg100mg£2,079.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
Clociguanil has antimalarial activity.
CAS:
3378-93-6
Formula:
C12H15Cl2N5O
Molecular Weight:
316.19
Purity:
0.98
SMILES:
CC1(C)N=C(N)N=C(N)N1OCc1ccc(Cl)c(Cl)c1

References

1. Auliff AM, Balu B, Chen N, O'Neil MT, Cheng Q, Adams JH. Functional analysis of Plasmodium vivax dihydrofolate reductase-thymidylate synthase genes through stable transformation of Plasmodium falciparum. PLoS One. 2012;7(7):e40416. doi: 10.1371/journal.pone.0040416. Epub 2012 Jul 9. PubMed PMID: 22792308; PubMed Central PMCID: PMC3392216. 2. Knight DJ, Peters W. The antimalarial activity of N-benzyloxydihydrotriazines. I. The activity of clociguanil (BRL 50216) against rodent malaria, and studies on its mode of action. Ann Trop Med Parasitol. 1980 Aug;74(4):393-404. PubMed PMID: 7006531. 3. Mookherjee S, Howard V, Nzila-Mouanda A, Watkins W, Sibley CH. Identification and analysis of dihydrofolate reductase alleles from Plasmodium falciparum present at low frequency in polyclonal patient samples. Am J Trop Med Hyg. 1999 Jul;61(1):131-40. PubMed PMID: 10432070. 4. O'Neil MT, Korsinczky ML, Gresty KJ, Auliff A, Cheng Q. A novel Plasmodium falciparum expression system for assessing antifolate resistance caused by mutant P. vivax dihydrofolate reductase-thymidylate synthase. J Infect Dis. 2007 Aug 1;196(3):467-74. Epub 2007 Jun 20. PubMed PMID: 17597462.