TargetMol

CL-184005

Product Code:
 
TAR-T27035
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27035-5mg5mg£850.00
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Quantity:
TAR-T27035-50mg50mg£1,661.00
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Quantity:
TAR-T27035-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
CL-184005 is a platelet activating factor (PAF) inhibitor. CL-184005 interferes with tumor necrosis factor synthesis. CL-184005 also dreases Spleen-associated tumor necrosis factor protein.
CAS:
140466-18-8
Formula:
C33H46NO7PS
Molecular Weight:
631.76
Purity:
0.98
SMILES:
CCCCCCCCCCCCCCOc1cccc(OP([O-])(=O)Oc2cccc(C[n+]3csc(C)c3)c2)c1C(=O)OC

References

1. Negro Alvarez JM, Miralles L?pez JC, Ortiz Mart?nez JL, Abell?n Alem?n A, Rubio del Barrio R. Platelet-activating factor antagonists. Allergol Immunopathol (Madr). 1997 Sep-Oct;25(5):249-58. Review. PubMed PMID: 9395010. 2. Chen J, Giris N. Species differences in PAF receptor binding in the lungs between hamster and guinea pig. J Lipid Mediat Cell Signal. 1997 Jun;16(2):63-74. PubMed PMID: 9172049. 3. Dirkes K, Harris BH, Connolly RJ, Schwaitzberg SD, Dinarello CA, Gelfand JA. Platelet activating factor-antagonist improves survival in experimental staphylococcal septicemia. J Pediatr Surg. 1994 Aug;29(8):1055-7; discussion 1057-8. PubMed PMID: 7965505. 4. DeJoy SQ, Jeyaseelan R Sr, Torley LW, Pickett WC, Wissner A, Wick MM, Oronsky AL, Kerwar SS. Effect of CL 184,005, a platelet-activating factor antagonist in a murine model of Staphylococcus aureus-induced gram-positive sepsis. J Infect Dis. 1994 Jan;169(1):150-6. PubMed PMID: 8277176.