TargetMol

CGP-28014

Product Code:
 
TAR-T26997
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26997-5mg5mg£850.00
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TAR-T26997-50mg50mg£1,661.00
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TAR-T26997-100mg100mg£2,079.00
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Further Information

Bioactivity:
CGP-28014 is an inhibitor of catechol-O-methyltransferase. CGP-28014 increases the renal excretion of both dopamine and dihydroxyphenylacetic acid (DOPAC) but does not affect renal sodium handling indicating a different mechanism of action. CGP-28014 significantly reduced the levels of homovanillic acid (HVA), but did not modify DA and 3,4-dihydroxyphenylacetic acid (DOPAC).
CAS:
111757-17-6
Formula:
C12H19N3O
Molecular Weight:
221.304
Purity:
0.98
SMILES:
CCCN(CCC)C=Nc1cccc(=O)[nH]1

References

1. Kambur O, Talka R, Ansah OB, Kontinen VK, Pertovaara A, Kalso E, M?nnist? PT. Inhibitors of catechol-O-methyltransferase sensitize mice to pain. Br J Pharmacol. 2010 Dec;161(7):1553-65. doi: 10.1111/j.1476-5381.2010.00999.x. PubMed PMID: 20726980; PubMed Central PMCID: PMC3010567. 2. Hansell P, Odlind C, M?nnist? PT. Different renal effects of two inhibitors of catechol-O-methylation in the rat: entacapone and CGP 28014. Acta Physiol Scand. 1998 Apr;162(4):489-94. PubMed PMID: 9597116. 3. M?nnist? PT. Catechol O-methyltransferase: characterization of the protein, its gene, and the preclinical pharmacology of COMT inhibitors. Adv Pharmacol. 1998;42:324-8. PubMed PMID: 9327906. 4. Psylla M, G?nther I, Antonini A, Vontobel P, Reist HW, Zollinger A, Leenders KL. Cerebral 6-[18F]fluoro-L-DOPA uptake in rhesus monkey: pharmacological influence of aromatic amino acid decarboxylase (AAAD) and catechol-O-methyltransferase (COMT) inhibition. Brain Res. 1997 Aug 29;767(1):45-54. PubMed PMID: 9365014.