TargetMol

Bucindolol hydrochloride

Product Code:
 
TAR-T26920
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26920-5mg5mg£850.00
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TAR-T26920-50mg50mg£1,661.00
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Quantity:
TAR-T26920-100mg100mg£2,079.00
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Further Information

Bioactivity:
Bucindolol is a beta-adrenergic receptor antagonist. Bucindolol is a fourth-generation β-blocker. Bucindolol prevented new-onset AF; β? and α(2c) polymorphisms predicted therapeutic response; and the 47% of patients who were β?389 Arg homozygotes had an enhanced effect size of 74%.
CAS:
70369-47-0
Formula:
C22H26ClN3O2
Molecular Weight:
399.92
Purity:
0.98
SMILES:
Cl.CC(C)(Cc1c[nH]c2ccccc12)NCC(O)COc1ccccc1C#N

References

1. Black-Maier E, Steinberg BA, Piccini JP. Bucindolol hydrochloride in atrial fibrillation and concomitant heart failure. Expert Rev Cardiovasc Ther. 2015 Jun;13(6):627-36. doi: 10.1586/14779072.2015.1031111. Epub 2015 May 11. Review. PubMed PMID: 25959096. 2. Aleong RG, Sauer WH, Sauer WH, Murphy GA, Port JD, Anand IS, Fiuzat M, O'Connor CM, Abraham WT, Liggett SB, Bristow MR. Prevention of atrial fibrillation by bucindolol is dependent on the beta?389 Arg/Gly adrenergic receptor polymorphism. JACC Heart Fail. 2013 Aug;1(4):338-44. PubMed PMID: 24159564; PubMed Central PMCID: PMC3804380. 3. Lymperopoulos A, Negussie S, Walklett K. ?1- and ?2C-adrenergic receptor polymorphisms and the antiarrhythmic effect of bucindolol in heart failure with reduced ejection fraction. Pharmacogenomics. 2013 Oct;14(13):1545-9. doi: 10.2217/pgs.13.137. PubMed PMID: 24088125. 4. Aleong RG, Sauer WH, Robertson AD, Liggett SB, Bristow MR. Adrenergic receptor polymorphisms and prevention of ventricular arrhythmias with bucindolol in patients with chronic heart failure. Circ Arrhythm Electrophysiol. 2013 Feb;6(1):137-43. doi: 10.1161/CIRCEP.111.969618. Epub 2012 Dec 30. PubMed PMID: 23275278.