TargetMol

BRD7539

Product Code:
 
TAR-T26900
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26900-5mg5mg£1,412.00
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TAR-T26900-50mg50mg£2,785.00
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Quantity:
TAR-T26900-100mg100mg£3,765.00
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Further Information

Bioactivity:
BRD7539B is a Dihydroorotate dehydrogenase (DHODH) inhibitor . RD7539 shows to target PfDHODH (IC50 = 0.033 μM) selectively over human (Hs) DHODH (IC50 > 50 μM).
CAS:
2057420-00-3
Formula:
C23H22FN3O2
Molecular Weight:
391.446
Purity:
0.98
SMILES:
CCCNC(=O)N1[C@H](CO)[C@H]([C@H]1C#N)c1ccc(cc1)C#Cc1cccc(F)c1

References

1. Kato N, Comer E, Sakata-Kato T, et al. Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. Nature. 2016 Oct 20;538(7625):344-349. doi: 10.1038/nature19804. PubMed PMID: 27602946. 2. Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase Micah MaetaniNobutaka KatoValquiria A. P. JaborFelipe A. CalilMaria Cristina NonatoChristina A. SchererStuart L. Schreiber Publication Date (Web): February 27, 2017 (Letter) doi: 10.1021/acsmedchemlett.7b00030