TargetMol

Braco-19

Product Code:
 
TAR-T26892
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
Braco-19 is a G-quadruplex ligand, it inhibits the growth of tumor.
CAS:
351351-75-2
Formula:
C35H43N7O2
Molecular Weight:
593.776
Purity:
0.98
SMILES:
CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1

References

1. Perrone R, Butovskaya E, Daelemans D, Pal? G, Pannecouque C, Richter SN. Anti-HIV-1 activity of the G-quadruplex ligand BRACO-19. J Antimicrob Chemother. 2014 Dec;69(12):3248-58. doi: 10.1093/jac/dku280. Epub 2014 Aug 6. PubMed PMID: 25103489. 2. Artusi S, Nadai M, Perrone R, Biasolo MA, Pal? G, Flamand L, Calistri A, Richter SN. The Herpes Simplex Virus-1 genome contains multiple clusters of repeated G-quadruplex: Implications for the antiviral activity of a G-quadruplex ligand. Antiviral Res. 2015 Jun;118:123-31. doi: 10.1016/j.antiviral.2015.03.016. Epub 2015 Apr 3. PubMed PMID: 25843424. 3. Debray J, Zeghida W, Jourdan M, Monchaud D, Dheu-Andries ML, Dumy P, Teulade-Fichou MP, Demeunynck M. Synthesis and evaluation of fused bispyrimidinoacridines as novel pentacyclic analogues of quadruplex-binder BRACO-19. Org Biomol Chem. 2009 Dec 21;7(24):5219-28. doi: 10.1039/b912716j. Epub 2009 Oct 21. PubMed PMID: 20024118. 4. Zhou G, Liu X, Li Y, Xu S, Ma C, Wu X, Cheng Y, Yu Z, Zhao G, Chen Y. Telomere targeting with a novel G-quadruplex-interactive ligand BRACO-19 induces T-loop disassembly and telomerase displacement in human glioblastoma cells. Oncotarget. 2016 Mar 22;7(12):14925-39. doi: 10.18632/oncotarget.7483. PubMed PMID: 26908447; PubMed Central PMCID: PMC4924762.