TargetMol

BPDBA

Product Code:
 
TAR-T26891
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26891-5mg5mg£125.00
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Quantity:
TAR-T26891-1mL1 mL * 10 mM (in DMSO)£149.00
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Quantity:
TAR-T26891-10mg10mg£158.00
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TAR-T26891-25mg25mg£254.00
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Quantity:
TAR-T26891-50mg50mg£367.00
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Quantity:
TAR-T26891-100mg100mg£545.00
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Quantity:
TAR-T26891-500mg500mg£1,083.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
BPDBA is a noncompetitive betaine/GABA transporter 1 (BGT1) inhibitor.
CAS:
312281-74-6
Formula:
C19H20Cl2N2O
Molecular Weight:
363.28
Pathway:
Neuroscience|Membrane transporter/Ion channel
Purity:
0.98
SMILES:
O=C(NC1CCN(CC2=CC=CC=C2)CC1)C3=CC=C(Cl)C=C3Cl
Target:
GABA Receptor

References

1. J?rgensen L, Al-Khawaja A, Kickinger S, Vogensen SB, Skovgaard-Petersen J, Rosenthal E, Borkar N, L?ffler R, Madsen KK, Br?uner-Osborne H, Schousboe A, Ecker GF, Wellendorph P, Clausen RP. Structure-Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/?-Aminobutyric Acid Transporter 1 (BGT1). J Med Chem. 2017 Nov 9;60(21):8834-8846. doi: 10.1021/acs.jmedchem.7b00924. Epub 2017 Oct 19. PubMed PMID: 28991462. 2. Kragholm B, Kvist T, Madsen KK, J?rgensen L, Vogensen SB, Schousboe A, Clausen RP, Jensen AA, Br?uner-Osborne H. Discovery of a subtype selective inhibitor of the human betaine/GABA transporter 1 (BGT-1) with a non-competitive pharmacological profile. Biochem Pharmacol. 2013 Aug 15;86(4):521-8. doi: 10.1016/j.bcp.2013.06.007. Epub 2013 Jun 19. PubMed PMID: 23792119.