TargetMol

AZ4800

Product Code:
 
TAR-T26706
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26706-5mg5mg£850.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T26706-50mg50mg£1,661.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T26706-100mg100mg£2,079.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
AZD4800 is a gamma secretase modulators.
CAS:
1226886-78-7
Formula:
C24H29N5O3
Molecular Weight:
435.528
Purity:
0.98
SMILES:
COc1cc(Nc2nc(COC3CCCC3)c3COCCc3n2)ccc1-n1cnc(C)c1

References

1. Str?mberg K, Eketj?ll S, Georgievska B, Tunblad K, Eliason K, Olsson F, Rades?ter AC, Klintenberg R, Arvidsson PI, von Berg S, F?lting J, Cowburn RF, Dabrowski M. Combining an amyloid-beta (A?) cleaving enzyme inhibitor with a ?-secretase modulator results in an additive reduction of A? production. FEBS J. 2015 Jan;282(1):65-73. doi: 10.1111/febs.13103. PubMed PMID: 25303711. 2. Borgegard T, Jur?us A, Olsson F, Rosqvist S, Sabirsh A, Rotticci D, Paulsen K, Klintenberg R, Yan H, Waldman M, Stromberg K, Nord J, Johansson J, Regner A, Parpal S, Malinowsky D, Radesater AC, Li T, Singh R, Eriksson H, Lundkvist J. First and second generation ?-secretase modulators (GSMs) modulate amyloid-? (A?) peptide production through different mechanisms. J Biol Chem. 2012 Apr 6;287(15):11810-9. doi: 10.1074/jbc.M111.305227. PubMed PMID: 22334705; PubMed Central PMCID: PMC3320929.