TargetMol

AVX-001

Product Code:
 
TAR-T26693
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26693-5mg5mg£930.00
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Quantity:
TAR-T26693-50mg50mg£1,821.00
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Quantity:
TAR-T26693-100mg100mg£2,319.00
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This product comes from: United States.
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Further Information

Bioactivity:
AVX-001, a cytosolic phospholipase A2 (cPLA2) inhibitor, is used potentially for the treatment of psoriasis.
CAS:
300553-18-8
Formula:
C21H29F3OS
Molecular Weight:
386.52
Purity:
0.98
SMILES:
CCC=C/CC=C/CC=C/CC=C/CCC=CCSCC(=O)C(F)(F)F

References

1. Omland SH, Habicht A, Damsbo P, Wilms J, Johansen B, Gniadecki R. A randomized, double-blind, placebo-controlled, dose-escalation first-in-man study (phase 0) to assess the safety and efficacy of topical cytosolic phospholipase A2 inhibitor, AVX001, in patients with mild to moderate plaque psoriasis. J Eur Acad Dermatol Venereol. 2017 Jan 20. doi: 10.1111/jdv.14128. [Epub ahead of print] PubMed PMID: 28107559. 2. Huwiler A, Feuerherm AJ, Sakem B, Pastukhov O, Filipenko I, Nguyen T, Johansen B. The ?3-polyunsaturated fatty acid derivatives AVX001 and AVX002 directly inhibit cytosolic phospholipase A(2) and suppress PGE(2) formation in mesangial cells. Br J Pharmacol. 2012 Dec;167(8):1691-701. doi: 10.1111/j.1476-5381.2012.02114.x. PubMed PMID: 22831644; PubMed Central PMCID: PMC3525871.