TargetMol

AV-101

Product Code:
 
TAR-T26686
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26686-5mg5mg£850.00
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TAR-T26686-50mg50mg£1,661.00
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Quantity:
TAR-T26686-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
AV-101 is a NMDA glycine B receptor antagonist.
CAS:
153152-32-0
Formula:
C10H11ClN2O3
Molecular Weight:
242.66
Purity:
0.98
SMILES:
N[C@@H](CC(=O)c1ccc(Cl)cc1N)C(O)=O

References

1. Zanos P, Piantadosi SC, Wu HQ, Pribut HJ, Dell MJ, Can A, Snodgrass HR, Zarate CA Jr, Schwarcz R, Gould TD. The Prodrug 4-Chlorokynurenine Causes Ketamine-Like Antidepressant Effects, but Not Side Effects, by NMDA/GlycineB-Site Inhibition. J Pharmacol Exp Ther. 2015 Oct;355(1):76-85. doi: 10.1124/jpet.115.225664. Epub 2015 Aug 11. PubMed PMID: 26265321; PubMed Central PMCID: PMC4576668. 2. Tan L, Yu JT, Tan L. The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations. J Neurol Sci. 2012 Dec 15;323(1-2):1-8. doi: 10.1016/j.jns.2012.08.005. Epub 2012 Aug 29. Review. PubMed PMID: 22939820. 3. Linderholm KR, Andersson A, Olsson S, Olsson E, Snodgrass R, Engberg G, Erhardt S. Activation of rat ventral tegmental area dopamine neurons by endogenous kynurenic acid: a pharmacological analysis. Neuropharmacology. 2007 Dec;53(8):918-24. Epub 2007 Sep 20. PubMed PMID: 17959203. 4. Wu HQ, Rassoulpour A, Goodman JH, Scharfman HE, Bertram EH, Schwarcz R. Kynurenate and 7-chlorokynurenate formation in chronically epileptic rats. Epilepsia. 2005 Jul;46(7):1010-6. PubMed PMID: 16026552.