TargetMol

5-Methylurapidil

Product Code:
 
TAR-T26393
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26393-5mg5mg£850.00
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Quantity:
TAR-T26393-50mg50mg£1,661.00
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Quantity:
TAR-T26393-100mg100mg£2,079.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
5-Methylurapidil is an alpha1A-adrenoceptor antagonist.
CAS:
34661-85-3
Formula:
C21H31N5O3
Molecular Weight:
401.511
Purity:
0.98
SMILES:
COc1ccccc1N1CCN(CCCNc2c(C)c(=O)n(C)c(=O)n2C)CC1

References

1. Arce C, Vicente D, Segura V, Flacco N, Mont? F, Almenar L, Ag?ero J, Rueda J, Jim?nez-Altay? F, Vila E, Noguera MA, D'Ocon P, Ivorra MD. Activation of ?(1A) -adrenoceptors desensitizes the rat aorta response to phenylephrine through a neuronal NOS pathway, a mechanism lost with ageing. Br J Pharmacol. 2017 Jul;174(13):2015-2030. doi: 10.1111/bph.13800. Epub 2017 May 10. PubMed PMID: 28369791; PubMed Central PMCID: PMC5466529. 2. Kazi RN, Sattar MA, Johns EJ. Antidiuretic and antinatriuretic response to high salt load in normotensive Wistar-Kyoto rats: Role of alpha-1A-adrenoreceptors. Auton Autacoid Pharmacol. 2017 Jan;37(1):13-18. doi: 10.1111/aap.12053. PubMed PMID: 28332265. 3. Thomas RC Jr, Cowley PM, Singh A, Myagmar BE, Swigart PM, Baker AJ, Simpson PC. The Alpha-1A Adrenergic Receptor in the Rabbit Heart. PLoS One. 2016 Jun 3;11(6):e0155238. doi: 10.1371/journal.pone.0155238. eCollection 2016. PubMed PMID: 27258143; PubMed Central PMCID: PMC4892533. 4. Ahmad A, Sattar MA, Azam M, Abdulla MH, Khan SA, Hashmi F, Abdullah NA, Johns EJ. Cystathione gamma lyase/Hydrogen Sulphide Pathway Up Regulation Enhances the Responsiveness of ?1A and ?1B-Adrenoreceptors in the Kidney of Rats with Left Ventricular Hypertrophy. PLoS One. 2016 May 18;11(5):e0154995. doi: 10.1371/journal.pone.0154995. eCollection 2016. PubMed PMID: 27191852; PubMed Central PMCID: PMC4871510.