TargetMol

4alpha-PDD

Product Code:
 
TAR-T26386
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26386-5mg5mg£1,080.00
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Further Information

Bioactivity:
4alpha-PDD activates transient receptor potential vanilloid 4 (TRPV4) channels and is inactive for signaling through PKC.
CAS:
27536-56-7
Formula:
C40H64O8
Molecular Weight:
672.944
Purity:
0.98
SMILES:
[H][C@@]12C=C(C)C(=O)[C@@]1(O)CC(CO)=C[C@@]1([H])[C@@H]3C(C)(C)[C@]3(OC(=O)CCCCCCCCC)[C@H](OC(=O)CCCCCCCCC)[C@@H](C)[C@]21O

References

1. Chen CK, Hsu PY, Wang TM, Miao ZF, Lin RT, Juo SH. TRPV4 Activation Contributes Functional Recovery from Ischemic Stroke via Angiogenesis and Neurogenesis. Mol Neurobiol. 2017 Jun 9. doi: 10.1007/s12035-017-0625-0. [Epub ahead of print] PubMed PMID: 28597396. 2. Kamakura T, Kondo M, Koyama Y, Hanada Y, Ishida Y, Nakamura Y, Yamada T, Takimoto Y, Kitahara T, Ozono Y, Horii A, Imai T, Inohara H, Shimada S. Functional Expression of an Osmosensitive Cation Channel, Transient Receptor Potential Vanilloid 4, in Rat Vestibular Ganglia. Audiol Neurootol. 2016;21(4):268-274. Epub 2016 Oct 6. PubMed PMID: 27705979. 3. Hong Z, Tian Y, Qi M, Li Y, Du Y, Chen L, Liu W, Chen L. Transient Receptor Potential Vanilloid 4 Inhibits ?-Aminobutyric Acid-Activated Current in Hippocampal Pyramidal Neurons. Front Mol Neurosci. 2016 Aug 26;9:77. doi: 10.3389/fnmol.2016.00077. eCollection 2016. PubMed PMID: 27616980; PubMed Central PMCID: PMC4999446. 4. Qu YJ, Zhang X, Fan ZZ, Huai J, Teng YB, Zhang Y, Yue SW. Effect of TRPV4-p38 MAPK Pathway on Neuropathic Pain in Rats with Chronic Compression of the Dorsal Root Ganglion. Biomed Res Int. 2016;2016:6978923. doi: 10.1155/2016/6978923. Epub 2016 Jun 5. PubMed PMID: 27366753; PubMed Central PMCID: PMC4913001.