TargetMol

1-Benzyl-I3C

Product Code:
 
TAR-T26378
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26378-5mg5mg£850.00
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TAR-T26378-50mg50mg£1,661.00
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Quantity:
TAR-T26378-100mg100mg£2,079.00
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Further Information

Bioactivity:
1-Benzyl-I3C is an NEDD4-1 inhibitor.
CAS:
60941-76-6
Formula:
C16H15NO
Molecular Weight:
237.302
Purity:
0.98
SMILES:
OCc1cn(Cc2ccccc2)c2ccccc12

References

1. Quirit JG, Lavrenov SN, Poindexter K, Xu J, Kyauk C, Durkin KA, Aronchik I, Tomasiak T, Solomatin YA, Preobrazhenskaya MN, Firestone GL. Indole-3-carbinol (I3C) analogues are potent small molecule inhibitors of NEDD4-1 ubiquitin ligase activity that disrupt proliferation of human melanoma cells. Biochem Pharmacol. 2017 Mar 1;127:13-27. doi: 10.1016/j.bcp.2016.12.007. Epub 2016 Dec 12. PubMed PMID: 27979631. 2. Aronchik I, Chen T, Durkin KA, Horwitz MS, Preobrazhenskaya MN, Bjeldanes LF, Firestone GL. Target protein interactions of indole-3-carbinol and the highly potent derivative 1-benzyl-I3C with the C-terminal domain of human elastase uncouples cell cycle arrest from apoptotic signaling. Mol Carcinog. 2012 Nov;51(11):881-94. doi: 10.1002/mc.20857. Epub 2011 Oct 19. PubMed PMID: 22012859. 3. Nguyen HH, Lavrenov SN, Sundar SN, Nguyen DH, Tseng M, Marconett CN, Kung J, Staub RE, Preobrazhenskaya MN, Bjeldanes LF, Firestone GL. 1-Benzyl-indole-3-carbinol is a novel indole-3-carbinol derivative with significantly enhanced potency of anti-proliferative and anti-estrogenic properties in human breast cancer cells. Chem Biol Interact. 2010 Aug 5;186(3):255-66. doi: 10.1016/j.cbi.2010.05.015. Epub 2010 Jun 2. PubMed PMID: 20570586; PubMed Central PMCID: PMC3422669.