TargetMol

18-Methoxycoronaridine

Product Code:
 
TAR-T26377
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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Further Information

Bioactivity:
18-Methoxycoronaridine is a nicotinic α3β4 antagonist. 18-Methoxycoronaridine slows the rate of induction of behavioral sensitization to nicotine. 18-MC inhibits α3β4 nicotinic acetylcholine receptors which are densely expressed in the medial habenula and interpeduncular nucleus. 18-Methoxycoronaridine also attenuates sucrose reward, decrease sucrose intake and prevent the development of sucrose-induced obesity.
CAS:
308123-60-6
Formula:
C22H28N2O3
Molecular Weight:
368.477
Purity:
0.98
SMILES:
[H][C@@]12[C@@H](CCOC)C[C@H]3CN1CCc1c([nH]c4ccccc14)[C@@]2(C3)C(=O)OC

References

1. Eggan BL, McCallum SE. 18-Methoxycoronaridine acts in the medial habenula to attenuate behavioral and neurochemical sensitization to nicotine. Behav Brain Res. 2016 Jul 1;307:186-93. doi: 10.1016/j.bbr.2016.04.008. PubMed PMID: 27059333. 2. Polston JE, Pritchett CE, Sell EM, Glick SD. 18-Methoxycoronaridine blocks context-induced reinstatement following cocaine self-administration in rats. Pharmacol Biochem Behav. 2012 Nov;103(1):83-94. PubMed PMID: 22885280; PubMed Central PMCID: PMC3526685. 3. Taraschenko OD, Maisonneuve IM, Glick SD. Sex differences in high fat-induced obesity in rats: Effects of 18-methoxycoronaridine. Physiol Behav. 2011 Jun 1;103(3-4):308-14. doi: 10.1016/j.physbeh.2011.02.011. PubMed PMID: 21324333. 4. McCallum SE, Taraschenko OD, Hathaway ER, Vincent MY, Glick SD. Effects of 18-methoxycoronaridine on ghrelin-induced increases in sucrose intake and accumbal dopamine overflow in female rats. Psychopharmacology (Berl). 2011 May;215(2):247-56. doi: 10.1007/s00213-010-2132-0. PubMed PMID: 21210086; PubMed Central PMCID: PMC3790315.