TargetMol

(-)-Agelastatin A

Product Code:
 
TAR-T26358
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26358-5mg5mg£1,251.00
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TAR-T26358-50mg50mg£2,464.00
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TAR-T26358-100mg100mg£3,283.00
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Further Information

Bioactivity:
(-)-Agelastatin A inhibits osteopontin-mediated adhesion, invasion, and colony formation.
CAS:
152406-28-5
Formula:
C12H13BrN4O3
Molecular Weight:
341.165
Purity:
0.98
SMILES:
[H][C@@]12C[C@@]3(O)N(C)C(=O)N[C@@]3([H])[C@]1([H])NC(=O)c1ccc(Br)n21

References

1. McClary B, Zinshteyn B, Meyer M, Jouanneau M, Pellegrino S, Yusupova G, Schuller A, Reyes JCP, Lu J, Guo Z, Ayinde S, Luo C, Dang Y, Romo D, Yusupov M, Green R, Liu JO. Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A. Cell Chem Biol. 2017 Apr 27. pii: S2451-9456(17)30106-X. doi: 10.1016/j.chembiol.2017.04.006. [Epub ahead of print] PubMed PMID: 28457705. 2. Lindel T. Chemistry and Biology of the Pyrrole-Imidazole Alkaloids. Alkaloids Chem Biol. 2017;77:117-219. doi: 10.1016/bs.alkal.2016.12.001. Epub 2017 Jan 20. PubMed PMID: 28212701. 3. Yoshimitsu T, Tun HW. Compounds, compositions, and methods of agelastatin alkaloids: patent evaluation of WO2015042239 (A1). Expert Opin Ther Pat. 2017 Feb;27(2):113-119. doi: 10.1080/13543776.2017.1273902. Epub 2017 Jan 5. PubMed PMID: 28056571. 4. Jouanneau M, McClary B, Reyes JC, Chen R, Chen Y, Plunkett W, Cheng X, Milinichik AZ, Albone EF, Liu JO, Romo D. Derivatization of agelastatin A leading to bioactive analogs and a trifunctional probe. Bioorg Med Chem Lett. 2016 Apr 15;26(8):2092-7. doi: 10.1016/j.bmcl.2016.02.051. Epub 2016 Feb 23. PubMed PMID: 26951751.