TargetMol

WS 9326A

Product Code:
 
TAR-T26333
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T26333-5mg5mg£850.00
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Further Information

Bioactivity:
WS 9326A is an antagonist of tachykinin receptor from Streptomyces violaceusniger.
CAS:
125774-71-2
Formula:
C54H68N8O13
Molecular Weight:
1037.181
Purity:
0.98
SMILES:
CCCC=Cc1ccccc1C=CC(=O)N[C@H]1[C@@H](C)OC(=O)[C@H](CO)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC(C)C)NC(=O)C(=Cc2ccc(O)cc2)N(C)C1=O)[C@@H](C)O

References

1. Desouky SE, Shojima A, Singh RP, Matsufuji T, Igarashi Y, Suzuki T, Yamagaki T, Okubo K, Ohtani K, Sonomoto K, Nakayama J. Cyclodepsipeptides produced by actinomycetes inhibit cyclic-peptide-mediated quorum sensing in Gram-positive bacteria. FEMS Microbiol Lett. 2015 Jul;362(14). pii: fnv109. doi: 10.1093/femsle/fnv109. Epub 2015 Jul 5. PubMed PMID: 26149266. 2. Yu Z, Vodanovic-Jankovic S, Kron M, Shen B. New WS9326A congeners from Streptomyces sp. 9078 inhibiting Brugia malayi asparaginyl-tRNA synthetase. Org Lett. 2012 Sep 21;14(18):4946-9. Epub 2012 Sep 12. PubMed PMID: 22967068; PubMed Central PMCID: PMC3460372. 3. Hayashi K, Hashimoto M, Shigematsu N, Nishikawa M, Ezaki M, Yamashita M, Kiyoto S, Okuhara M, Kohsaka M, Imanaka H. WS9326A, a novel tachykinin antagonist isolated from Streptomyces violaceusniger no. 9326. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1992 Jul;45(7):1055-63. PubMed PMID: 1381343. 4. Shigematsu N, Kayakiri N, Okada S, Tanaka H. Total synthesis of WS9326A, a potent tachykinin antagonist from Streptomyces violaceoniger. Chem Pharm Bull (Tokyo). 1997 Feb;45(2):236-42. PubMed PMID: 9118439.