TargetMol

VU0366248

Product Code:
 
TAR-T26327
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26327-5mg5mg£850.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T26327-50mg50mg£1,661.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T26327-100mg100mg£2,079.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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  • Further Information
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Further Information

Bioactivity:
VU0366248 is a mGlu5 negative allosteric modulator.
CAS:
1243310-20-4
Formula:
C14H7ClF2N2O
Molecular Weight:
292.67
Purity:
0.98
SMILES:
Fc1cc(cc(c1)C(=O)Nc1cccc(Cl)c1F)C#N

References

1. Identification of Specific Ligand?Receptor Interactions That Govern Binding and Cooperativity of Diverse Modulators to a Common Metabotropic Glutamate Receptor 5 Allosteric Site Karen J. Gregory, Elizabeth D. Nguyen, Chrysa Malosh, Jeffrey L. Mendenhall, Jessica Z. Zic, Brittney S. Bates, Meredith J. Noetzel, Emma F. Squire, Eric M. Turner, Jerri M. Rook, Kyle A. Emmitte, Shaun R. Stauffer, Craig W. Lindsley, Jens Meiler, P. Jeffrey Conn ACS Chem Neurosci. 2014 Apr 16; 5(4): 282?295. Published online 2014 Feb 16. doi: 10.1021/cn400225x PMCID: PMC3990945 2. Investigating Metabotropic Glutamate Receptor 5 Allosteric Modulator Cooperativity, Affinity, and Agonism: Enriching Structure-Function Studies and Structure-Activity Relationships Karen J. Gregory, Meredith J. Noetzel, Jerri M. Rook, Paige N. Vinson, Shaun R. Stauffer, Alice L. Rodriguez, Kyle A. Emmitte, Ya Zhou, Aspen C. Chun, Andrew S. Felts, Brian A. Chauder, Craig W. Lindsley, Colleen M. Niswender, P. Jeffrey Conn Mol Pharmacol. 2012 Nov; 82(5): 860?875. doi: 10.1124/mol.112.080531 PMCID: PMC3477233 3. VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy Hilary Highfield Nickols, Joannes P. Yuh, Karen J. Gregory, Ryan D. Morrison, Brittney S. Bates, Shaun R. Stauffer, Kyle A. Emmitte, Michael Bubser, Weimin Peng, Michael T. Nedelcovych, Analisa Thompson, Xiaohui Lv, Zixiu Xiang, J. Scott Daniels, Colleen M. Niswender, Craig W. Lindsley, Carrie K. Jones, P. Jeffrey Conn J Pharmacol Exp Ther. 2016 Jan; 356(1): 123?136. Published online 2016 Jan. doi: 10.1124/jpet.115.226597 PMCID: PMC4702078 4. Molecular Insights into Metabotropic Glutamate Receptor Allosteric Modulation Karen J. Gregory, P. Jeffrey Conn Mol Pharmacol. 2015 Jul; 88(1): 188?202. Published online 2015 Jul. doi: 10.1124/mol.114.097220 PMCID: PMC4468636