TargetMol

RO5527239

Product Code:
 
TAR-T26108
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26108-5mg5mg£1,091.00
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TAR-T26108-50mg50mg£2,143.00
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Quantity:
TAR-T26108-100mg100mg£2,801.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
RO5527239 is a potent, orally available GPBAR1 agonist agent.
CAS:
1354812-99-9
Formula:
C28H31N3O3
Molecular Weight:
457.574
Purity:
0.98
SMILES:
Cc1cc(ccn1)C(C[C@H](c1ccc(cc1)N1CCC(CC1)C(O)=O)c1ccccc1C)=N/O

References

1. Dehmlow H, Alvarez S?nchez R, Bachmann S, Bissantz C, Bliss F, Conde-Knape K, Graf M, Martin RE, Obst Sander U, Raab S, Richter HG, Sewing S, Sprecher U, Ullmer C, Mattei P. Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4627-32. doi: 10.1016/j.bmcl.2013.06.017. Epub 2013 Jun 19. PubMed PMID: 23831134. 2. Ullmer C, Alvarez Sanchez R, Sprecher U, Raab S, Mattei P, Dehmlow H, Sewing S, Iglesias A, Beauchamp J, Conde-Knape K. Systemic bile acid sensing by G protein-coupled bile acid receptor 1 (GPBAR1) promotes PYY and GLP-1 release. Br J Pharmacol. 2013 Jun;169(3):671-84. doi: 10.1111/bph.12158. PubMed PMID: 23488746; PubMed Central PMCID: PMC3682713.