TargetMol

RAD-140-Q

Product Code:
 
TAR-T26037
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26037-5mg5mg£850.00
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Quantity:
TAR-T26037-50mg50mg£1,661.00
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Quantity:
TAR-T26037-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
RAD-140-Q (RAD-140) is a selective androgen receptor modulator that inhibits the Growth of Androgen/Estrogen Receptor-Positive Breast Cancer Models with a Distinct Mechanism of Action. RAD-140-Q is neuroprotective in cultured neurons and kainate-lesioned male rats.
CAS:
36191-21-6
Formula:
C15H23ClN2O
Molecular Weight:
282.81
Purity:
0.98
SMILES:
CN(CCCCCl)CC(=O)Nc1c(C)cccc1C

References

1. Yu Z, He S, Wang D, Patel HK, Miller CP, Brown JL, Hattersley G, Saeh JC. Selective Androgen Receptor Modulator RAD140 Inhibits the Growth of Androgen/Estrogen Receptor-Positive Breast Cancer Models with a Distinct Mechanism of Action. Clin Cancer Res. 2017 Dec 15;23(24):7608-7620. doi: 10.1158/1078-0432.CCR-17-0670. Epub 2017 Oct 3. PubMed PMID: 28974548. 2. Jayaraman A, Christensen A, Moser VA, Vest RS, Miller CP, Hattersley G, Pike CJ. Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats. Endocrinology. 2014 Apr;155(4):1398-406. doi: 10.1210/en.2013-1725. Epub 2014 Jan 15. PubMed PMID: 24428527; PubMed Central PMCID: PMC3959610. 3. Thevis M, Piper T, Beuck S, Geyer H, Sch?nzer W. Expanding sports drug testing assays: mass spectrometric characterization of the selective androgen receptor modulator drug candidates RAD140 and ACP-105. Rapid Commun Mass Spectrom. 2013 Jun 15;27(11):1173-82. doi: 10.1002/rcm.6558. PubMed PMID: 23650030. 4. Miller CP, Shomali M, Lyttle CR, O'Dea LS, Herendeen H, Gallacher K, Paquin D, Compton DR, Sahoo B, Kerrigan SA, Burge MS, Nickels M, Green JL, Katzenellenbogen JA, Tchesnokov A, Hattersley G. Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140. ACS Med Chem Lett. 2010 Dec 2;2(2):124-9. doi: 10.1021/ml1002508. eCollection 2011 Feb 10. PubMed PMID: 24900290; PubMed Central PMCID: PMC4018048.