TargetMol

Vismodegib

Product Code:
 
TAR-T2590
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T2590-5mg5mg£101.00
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TAR-T2590-10mg10mg£113.00
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TAR-T2590-1mL1 mL * 10 mM (in DMSO)£116.00
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TAR-T2590-50mg50mg£124.00
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TAR-T2590-100mg100mg£139.00
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TAR-T2590-200mg200mg£159.00
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Further Information

Bioactivity:
Vismodegib is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: 3.0 μM), ABCG2 (IC50: 1.4 μM).
CAS:
879085-55-9
Formula:
C19H14Cl2N2O3S
Molecular Weight:
421.29
Pathway:
Stem Cells; GPCR/G Protein; Autophagy; Membrane transporter/Ion channel
Purity:
0.9999
SMILES:
CS(=O)(=O)c1ccc(C(=O)Nc2ccc(Cl)c(c2)-c2ccccn2)c(Cl)c1
Target:
Hedgehog/Smoothened; ABC; Autophagy

References

1. Scales SJ, et al. Mechanisms of Hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci. 2009 Jun;30(6):303-12. 2. Zhang Y, et al. Hedgehog pathway inhibitor HhAntag691 is a potent inhibitor of ABCG2/BCRP and ABCB1/Pgp. Neoplasia. 2009 Jan;11(1):96-101. 3. Tian F, et al. The hedgehog pathway inhibitor GDC-0449 alters intracellular Ca2+ homeostasis and inhibits cell growth in cisplatin-resistant lung cancer cells. Anticancer Res. 2012 Jan;32(1):89-94. 4. Wong H, et al. Pharmacokinetic-pharmacodynamic analysis of vismodegib in preclinical models of mutational and ligand-dependent Hedgehog pathway activation. Clin Cancer Res. 2011 Jul 15;17(14):4682-92.