TargetMol

Laccaic acid A

Product Code:
 
TAR-T25594
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T25594-5mg5mg£850.00
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Further Information

Bioactivity:
Laccaic acid A is a direct, DNA-competitive DNA methyltransferase 1 inhibitor.
CAS:
15979-35-8
Formula:
C26H19NO12
Molecular Weight:
537.433
Purity:
0.98
SMILES:
CC(=O)NCCc1ccc(O)c(c1)-c1c(O)c(O)c2C(=O)c3cc(O)c(C(O)=O)c(C(O)=O)c3C(=O)c2c1O

References

1. Fagan RL, Cryderman DE, Kopelovich L, Wallrath LL, Brenner C. Laccaic acid A is a direct, DNA-competitive inhibitor of DNA methyltransferase 1. J Biol Chem. 2013 Aug 16;288(33):23858-67. doi: 10.1074/jbc.M113.480517. Epub 2013 Jul 9. PubMed PMID: 23839987; PubMed Central PMCID: PMC3745332. 2. Dokmaisrijan S, Payaka A, Tantishaiyakul V, Chairat M, Nimmanpipug P, Lee VS. Conformations and spectroscopic properties of laccaic acid A in the gas phase and in implicit water. Spectrochim Acta A Mol Biomol Spectrosc. 2013 Mar 15;105:125-34. doi: 10.1016/j.saa.2012.11.105. Epub 2012 Dec 13. PubMed PMID: 23295218. 3. Sekido C, Nishimura N, Takai M, Hasumi K. Inhibition of plasma hyaluronan-binding protein autoactivation by laccaic acid. Biosci Biotechnol Biochem. 2010;74(11):2320-2. Epub 2010 Nov 7. PubMed PMID: 21071862. 4. Dube DK, Loch-Caruso R, Trosko JE, Chakravarty I, Ghosh A, Loeb LA. Assessment of the carcinogenic potential of a proposed food coloring additive, laccaic acid, using short-term assays. Cell Biol Toxicol. 1984 Oct;1(1):111-25. PubMed PMID: 6401125.