TargetMol

ICI 198583

Product Code:
 
TAR-T25519
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25519-5mg5mg£930.00
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TAR-T25519-50mg50mg£1,821.00
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Quantity:
TAR-T25519-100mg100mg£2,319.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
ICI 198583 is an inhibitor of antifolate thymidylate synthase.
CAS:
112887-62-4
Formula:
C25H24N4O6
Molecular Weight:
476.489
Purity:
0.98
SMILES:
Cc1nc(=O)c2cc(CN(CC#C)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)ccc2[nH]1

References

1. Chen JH, Zhang N, Wang YQ, Wang JZ, Ji SX, Dang WJ, Li SM, Feng L. Estrogenic effects of flavonoid components in Xiaoyao powder. Genet Mol Res. 2016 Feb 11;15(1). doi: 10.4238/gmr.15017500. PubMed PMID: 26909969. 2. Pawe?czak K, Makowski M, Kempny M, Dzik JM, Go?os B, Rode W, Rzeszotarska B. Sulfamide antifolates inhibiting thymidylate synthase: synthesis, enzyme inhibition and cytotoxicity. Acta Biochim Pol. 2002;49(2):407-20. PubMed PMID: 12362982. 3. Kusakiewicz-Dawid A, Bugaj M, Dzik JM, Go?os B, Wi?ska P, Pawe?czak K, Rzeszotarska B, Rode W. Synthesis and biological activity of N(alpha)-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-propargylami no]phenylacetyl]-L-glutamic acid. Acta Biochim Pol. 2002;49(1):197-203. PubMed PMID: 12136941. 4. Skelton LA, Ormerod MG, Titley JC, Jackman AL. Cell cycle effects of CB30865, a lipophilic quinazoline-based analogue of the antifolate thymidylate synthase inhibitor ICI 198583 with an undefined mechanism of action. Cytometry. 1998 Sep 1;33(1):56-66. PubMed PMID: 9725559.