TargetMol

GKA-71

Product Code:
 
TAR-T25452
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25452-5mg5mg£850.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T25452-50mg50mg£1,661.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T25452-100mg100mg£2,079.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
GKA-71 is an effective glucokinase activator (GKA).
CAS:
863504-35-2
Formula:
C21H23N3O6S2
Molecular Weight:
477.55
Purity:
0.98
SMILES:
COC[C@H](C)Oc1cc(Oc2ccc(cc2)S(C)(=O)=O)cc(c1)C(=O)Nc1nc(C)ns1

References

1. Baker DJ, Wilkinson GP, Atkinson AM, Jones HB, Coghlan M, Charles AD, Leighton B. Chronic glucokinase activator treatment at clinically translatable exposures gives durable glucose lowering in two animal models of type 2 diabetes. Br J Pharmacol. 2014 Apr;171(7):1642-54. PubMed PMID: 24772484; PubMed Central PMCID: PMC3966745. 2. Winzell MS, Coghlan M, Leighton B, Frangioudakis G, Smith DM, Storlien LH, Ahr?n B. Chronic glucokinase activation reduces glycaemia and improves glucose tolerance in high-fat diet fed mice. Eur J Pharmacol. 2011 Aug 1;663(1-3):80-6. doi: 10.1016/j.ejphar.2011.05.009. Epub 2011 May 11. PubMed PMID: 21586282. 3. Gill D, Brocklehurst KJ, Brown HW, Smith DM. Upregulation of ?-cell genes and improved function in rodent islets following chronic glucokinase activation. J Mol Endocrinol. 2011 Jul 18;47(1):59-67. doi: 10.1530/JME-10-0157. Print 2011 Aug. PubMed PMID: 21571864.