TargetMol

Flopristin

Product Code:
 
TAR-T25424
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T25424-5mg5mg£850.00
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This product comes from: United States.
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Further Information

Bioactivity:
Flopristin, a semi-synthetic antibiotic of the streptogramin A class, is a fluorinated derivative of pristinamycin IIB.
CAS:
318498-76-9
Formula:
C28H38FN3O6
Molecular Weight:
531.625
Purity:
0.98
SMILES:
CC(C)[C@H]1OC(=O)[C@H]2CCCN2C(=O)c2coc(C[C@H](F)C[C@H](O)C=C(/C)C=CCNC(=O)C=C[C@H]1C)n2

References

1. Politano AD, Sawyer RG. NXL-103, a combination of flopristin and linopristin, for the potential treatment of bacterial infections including community-acquired pneumonia and MRSA. Curr Opin Investig Drugs. 2010 Feb;11(2):225-36. Review. PubMed PMID: 20112172; PubMed Central PMCID: PMC3033781. 2. Noeske J, Huang J, Olivier NB, Giacobbe RA, Zambrowski M, Cate JH. Synergy of streptogramin antibiotics occurs independently of their effects on translation. Antimicrob Agents Chemother. 2014 Sep;58(9):5269-79. doi: 10.1128/AAC.03389-14. Epub 2014 Jun 23. PubMed PMID: 24957822; PubMed Central PMCID: PMC4135883. 3. Vidaillac C, Parra-Ruiz J, Winterfield P, Rybak MJ. In vitro pharmacokinetic/pharmacodynamic activity of NXL103 versus clindamycin and linezolid against clinical Staphylococcus aureus and Streptococcus pyogenes isolates. Int J Antimicrob Agents. 2011 Oct;38(4):301-6. doi: 10.1016/j.ijantimicag.2011.04.023. Epub 2011 Jul 20. PubMed PMID: 21764263.