TargetMol

UCD38B HCl

Product Code:
 
TAR-T24920
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T24920-5mg5mg£850.00
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Further Information

Bioactivity:
UCD38B HCl is a cell-permeable intracellular uPA inhibitor that acts by killing proliferative and non-proliferative high-grade glioma cells by programmed necrosis.
CAS:
1115177-19-9
Formula:
C15H17Cl2N7O3
Molecular Weight:
414.25
Purity:
0.98
SMILES:
Cl.NC(=N)NC(=O)c1nc(Cl)c(NCC(=O)OCc2ccccc2)nc1N

References

1. Gorin FA, Pasupuleti N, Mahajan D, Dugar S. Killing Glioma 'Stem-like' Cells via Drug-Induced Relocation of Endosomal Urokinase Proteins. Anticancer Agents Med Chem. 2017;17(1):40-47. Review. PubMed PMID: 27357540. 2. Pasupuleti N, Grodzki AC, Gorin F. Mis-trafficking of endosomal urokinase proteins triggers drug-induced glioma nonapoptotic cell death. Mol Pharmacol. 2015 Apr;87(4):683-96. doi: 10.1124/mol.114.096602. Epub 2015 Jan 29. PubMed PMID: 25634671; PubMed Central PMCID: PMC4366798. 3. Leon LJ, Pasupuleti N, Gorin F, Carraway KL 3rd. A cell-permeant amiloride derivative induces caspase-independent, AIF-mediated programmed necrotic death of breast cancer cells. PLoS One. 2013 Apr 30;8(4):e63038. doi: 10.1371/journal.pone.0063038. Print 2013. PubMed PMID: 23646172; PubMed Central PMCID: PMC3639988. 4. Pasupuleti N, Leon L, Carraway KL 3rd, Gorin F. 5-Benzylglycinyl-amiloride kills proliferating and nonproliferating malignant glioma cells through caspase-independent necroptosis mediated by apoptosis-inducing factor. J Pharmacol Exp Ther. 2013 Mar;344(3):600-15. doi: 10.1124/jpet.112.200519. Epub 2012 Dec 14. PubMed PMID: 23241369; PubMed Central PMCID: PMC3583503.