TargetMol

Ro 25-6981 HCl

Product Code:
 
TAR-T24717
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T24717-5mg5mg£850.00
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TAR-T24717-50mg50mg£1,661.00
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TAR-T24717-100mg100mg£2,079.00
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Further Information

Bioactivity:
Ro 25-6981 HCl is an effective and selective NMDA glutamate receptors containing the NR2B subunit antagonist.
CAS:
919289-58-0
Formula:
C22H30ClNO2
Molecular Weight:
375.94
Purity:
0.98
SMILES:
Cl.C[C@@H](CN1CCC(Cc2ccccc2)CC1)[C@@H](O)c1ccc(O)cc1

References

1. Maranis S, Stamatis D, Tsironis C, Konitsiotis S. Investigation of the antidyskinetic site of action of metabotropic and ionotropic glutamate receptor antagonists. Intracerebral infusions in 6-hydroxydopamine-lesioned rats with levodopa-induced dyskinesia. Eur J Pharmacol. 2012 May 15;683(1-3):71-7. doi: 10.1016/j.ejphar.2012.02.036. Epub 2012 Mar 4. PubMed PMID: 22410193. 2. Gagolewicz PJ, Dringenberg HC. NR2B-subunit dependent facilitation of long-term potentiation in primary visual cortex following visual discrimination training of adult rats. Eur J Neurosci. 2011 Oct;34(8):1222-9. doi: 10.1111/j.1460-9568.2011.07842.x. Epub 2011 Sep 6. PubMed PMID: 21895803. 3. Rammes G, Hasenj?ger A, Sroka-Saidi K, Deussing JM, Parsons CG. Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of ?-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices. Neuropharmacology. 2011 May;60(6):982-90. doi: 10.1016/j.neuropharm.2011.01.051. Epub 2011 Feb 12. PubMed PMID: 21310164. 4. Haseneder R, Kratzer S, Kochs E, H?felmann D, Auberson Y, Eder M, Rammes G. The xenon-mediated antagonism against the NMDA receptor is non-selective for receptors containing either NR2A or NR2B subunits in the mouse amygdala. Eur J Pharmacol. 2009 Oct 1;619(1-3):33-7. doi: 10.1016/j.ejphar.2009.08.011. Epub 2009 Aug 15. PubMed PMID: 19686722.