TargetMol

Palmostatin B

Product Code:
 
TAR-T24591
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24591-5mg5mg£850.00
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TAR-T24591-50mg50mg£1,661.00
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Quantity:
TAR-T24591-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Palmostatin B is a modulator of Ras-signaling that acts by targeting acyl protein thioesterase 1 (APT1) and 2 (APT2) in cells.
CAS:
1233365-12-2
Formula:
C23H36O4
Molecular Weight:
376.537
Purity:
0.98
SMILES:
CCCCCCCCCC[C@H]1[C@H](CCc2ccc(OC)c(OC)c2)OC1=O

References

1. Zhang J, Huang Y, Chen J, Zhu H, Whiteheart SW. Dynamic cycling of t-SNARE acylation regulates platelet exocytosis. J Biol Chem. 2018 Mar 9;293(10):3593-3606. doi: 10.1074/jbc.RA117.000140. Epub 2018 Jan 19. PubMed PMID: 29352103; PubMed Central PMCID: PMC5846156. 2. Qiu T, Kathayat RS, Cao Y, Beck MW, Dickinson BC. A Fluorescent Probe with Improved Water Solubility Permits the Analysis of Protein S-Depalmitoylation Activity in Live Cells. Biochemistry. 2018 Jan 16;57(2):221-225. doi: 10.1021/acs.biochem.7b00835. Epub 2017 Oct 18. PubMed PMID: 29023093; PubMed Central PMCID: PMC5823605. 3. Lin DTS, Davis NG, Conibear E. Targeting the Ras palmitoylation/depalmitoylation cycle in cancer. Biochem Soc Trans. 2017 Aug 15;45(4):913-921. doi: 10.1042/BST20160303. Epub 2017 Jun 19. Review. PubMed PMID: 28630138. 4. Turcotte C, Zarini S, Jean S, Martin C, Murphy RC, Marsolais D, Laviolette M, Blanchet MR, Flamand N. The Endocannabinoid Metabolite Prostaglandin E(2) (PGE(2))-Glycerol Inhibits Human Neutrophil Functions: Involvement of Its Hydrolysis into PGE(2) and EP Receptors. J Immunol. 2017 Apr 15;198(8):3255-3263. doi: 10.4049/jimmunol.1601767. Epub 2017 Mar 3. PubMed PMID: 28258202.