TargetMol

OSI-7904L free acid

Product Code:
 
TAR-T24572
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24572-5mg5mg£1,332.00
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Quantity:
TAR-T24572-50mg50mg£2,625.00
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Quantity:
TAR-T24572-100mg100mg£3,524.00
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This product comes from: United States.
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Further Information

Bioactivity:
OSI-7904L is a folate-based thymidylate synthase inhibitor. It also has antimalarial and antitumor properties.
CAS:
139987-54-5
Formula:
C27H24N4O6
Molecular Weight:
500.51
Purity:
0.98
SMILES:
O=C(O)[C@@H](N(CC1=C2C=CC(NCC3=CC=C4C(C5=C(N=C(C)NC5=O)C=C4)=C3)=C1)C2=O)CCC(O)=O

References

1. Smith GK, Amyx H, Boytos CM, Duch DS, Ferone R, Wilson HR. Enhanced antitumor activity for the thymidylate synthase inhibitor 1843U89 through decreased host toxicity with oral folic acid. Cancer Res. 1995 Dec 15;55(24):6117-25. PubMed PMID: 8521402. 2. Hanlon MH, Ferone R. In vitro uptake, anabolism, and cellular retention of 1843U89 and other benzoquinazoline inhibitors of thymidylate synthase. Cancer Res. 1996 Jul 15;56(14):3301-6. PubMed PMID: 8764125. 3. Wilson RH. Novel therapeutic developments other than EGFR and VEGF inhibition in colorectal cancer. Oncologist. 2006 Oct;11(9):1018-24. Review. PubMed PMID: 17030644. 4. Li WW, Tong WP, Bertino JR. Antitumor activity of antifolate inhibitors of thymidylate and purine synthesis in human soft tissue sarcoma cell lines with intrinsic resistance to methotrexate. Clin Cancer Res. 1995 Jun;1(6):631-6. PubMed PMID: 9816025.