TargetMol

LIMK-IN-14

Product Code:
 
TAR-T24409
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24409-5mg5mg£850.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T24409-50mg50mg£1,661.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T24409-100mg100mg£2,079.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
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This product comes from: United States.
Typical lead time: 10-14 working days.
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  • Further Information
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Further Information

Bioactivity:
LIMK-IN-14 is an effective and selective inhibitor of LIMK.
CAS:
1116570-97-8
Formula:
C22H27N7O3
Molecular Weight:
437.504
Purity:
0.98
SMILES:
C[C@H]1CN(CCN1C(=O)Nc1cccc(OC(=O)N(C)C)c1)c1ncnc2[nH]cc(C)c12

References

1. Shaw PX, Sang A, Wang Y, Ho D, Douglas C, Dia L, Goldberg JL. Topical administration of a Rock/Net inhibitor promotes retinal ganglion cell survival and axon regeneration after optic nerve injury. Exp Eye Res. 2017 May;158:33-42. doi: 10.1016/j.exer.2016.07.006. Epub 2016 Jul 18. PubMed PMID: 27443501. 2. Kang CG, Han HJ, Lee HJ, Kim SH, Lee EO. Rho-associated kinase signaling is required for osteopontin-induced cell invasion through inactivating cofilin in human non-small cell lung cancer cell lines. Bioorg Med Chem Lett. 2015 May 1;25(9):1956-60. doi: 10.1016/j.bmcl.2015.03.024. Epub 2015 Mar 14. PubMed PMID: 25817589. 3. Mardilovich K, Gabrielsen M, McGarry L, Orange C, Patel R, Shanks E, Edwards J, Olson MF. Elevated LIM kinase 1 in nonmetastatic prostate cancer reflects its role in facilitating androgen receptor nuclear translocation. Mol Cancer Ther. 2015 Jan;14(1):246-58. doi: 10.1158/1535-7163.MCT-14-0447. Epub 2014 Oct 24. PubMed PMID: 25344584; PubMed Central PMCID: PMC4297197.