TargetMol

L 756423

Product Code:
 
TAR-T24362
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24362-1mg1mg£384.00
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Quantity:
TAR-T24362-5mg5mg£816.00
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TAR-T24362-10mg10mg£1,083.00
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TAR-T24362-25mg25mg£1,581.00
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Quantity:
TAR-T24362-50mg50mg£2,103.00
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Quantity:
TAR-T24362-100mg100mg£2,817.00
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Quantity:
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
L 756423 is an inhibitor of HIV Protease.
CAS:
216863-66-0
Formula:
C39H48N4O5
Molecular Weight:
652.836
Pathway:
Microbiology/Virology|Proteases/Proteasome
Purity:
0.98
SMILES:
CC(C)(C)NC(=O)[C@@H]1CN(Cc2cc3ccccc3o2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H]1[C@H](O)Cc2ccccc12
Target:
HIV Protease

References

1. Rose MJ, Merschman SA, Eisenhandler R, Woolf EJ, Yeh KC, Lin L, Fang W, Hsieh J, Braun MP, Gatto GJ, Matuszewski BK. High-throughput simultaneous determination of the HIV protease inhibitors indinavir and L-756423 in human plasma using semi-automated 96-well solid phase extraction and LC-MS/MS. J Pharm Biomed Anal. 2000 Dec 15;24(2):291-305. PubMed PMID: 11130208. 2. Dorsey BD, McDonough C, McDaniel SL, Levin RB, Newton CL, Hoffman JM, Darke PL, Zugay-Murphy JA, Emini EA, Schleif WA, Olsen DB, Stahlhut MW, Rutkowski CA, Kuo LC, Lin JH, Chen IW, Michelson SR, Holloway MK, Huff JR, Vacca JP. Identification of MK-944a: a second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitors. J Med Chem. 2000 Sep 7;43(18):3386-99. PubMed PMID: 10978186. 3. Munshi S, Chen Z, Yan Y, Li Y, Olsen DB, Schock HB, Galvin BB, Dorsey B, Kuo LC. An alternate binding site for the P1-P3 group of a class of potent HIV-1 protease inhibitors as a result of concerted structural change in the 80s loop of the protease. Acta Crystallogr D Biol Crystallogr. 2000 Apr;56(Pt 4):381-8. PubMed PMID: 10739910. 4. Rose MJ, Merschman SA, Woolf EJ, Matuszewski BK. Determination of L-756 423, a novel HIV protease inhibitor, in human plasma and urine using high-performance liquid chromatography with fluorescence detection. J Chromatogr B Biomed Sci Appl. 1999 Sep 24;732(2):425-35. PubMed PMID: 10517365.