TargetMol

L 647318

Product Code:
 
TAR-T24303
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24303-5mg5mg£850.00
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Quantity:
TAR-T24303-50mg50mg£1,661.00
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Quantity:
TAR-T24303-100mg100mg£2,079.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
L 647318 is an inhibitor of Hydroxymethylglutaryl-CoA reductase.
CAS:
87770-13-6
Formula:
C25H42O5
Molecular Weight:
422.606
Purity:
0.98
SMILES:
[H][C@@]12CC[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@]1([H])[C@H](C[C@@H](C)C2)OC(=O)C(C)(C)CC

References

1. Smith PF, Eydelloth RS, Grossman SJ, Stubbs RJ, Schwartz MS, Germershausen JI, MacDonald JS. Myopathy associated with HMG-CoA reductase inhibitors (HMGRIs) and cyclosporin A: evaluation in a rat model. Eur Heart J. 1992 Jul;13 Suppl B:2-6. PubMed PMID: 1644096. 2. Smith PF, Eydelloth RS, Grossman SJ, Stubbs RJ, Schwartz MS, Germershausen JI, Vyas KP, Kari PH, MacDonald JS. HMG-CoA reductase inhibitor-induced myopathy in the rat: cyclosporine A interaction and mechanism studies. J Pharmacol Exp Ther. 1991 Jun;257(3):1225-35. PubMed PMID: 1904494. 3. Kaufman MJ. Applications of oxygen polarography to drug stability testing and formulation development: solution-phase oxidation of hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. Pharm Res. 1990 Mar;7(3):289-92. PubMed PMID: 2339104.