TargetMol

J-104871

Product Code:
 
TAR-T24188
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24188-5mg5mg£1,412.00
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TAR-T24188-50mg50mg£2,785.00
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Quantity:
TAR-T24188-100mg100mg£3,765.00
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Further Information

Bioactivity:
J-104871 is an FTase inhibitor. J-104871 inhibits FTase in an FPP-competitive manner in whole cells as well as in the in vitro system. J-104871 suppressed tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells.
CAS:
191088-19-4
Formula:
C38H32N2O12
Molecular Weight:
708.676
Purity:
0.98
SMILES:
C[C@H]([C@H](CC=Cc1nc2ccccc2o1)c1ccc2OCOc2c1)N(Cc1ccc2ccccc2c1)C(=O)[C@H]1OC(O[C@H]1C(O)=O)(C(O)=O)C(O)=O

References

1. Yonemoto M, Satoh T, Arakawa H, Suzuki-Takahashi I, Monden Y, Kodera T, Tanaka K, Aoyama T, Iwasawa Y, Kamei T, Nishimura S, Tomimoto K. J-104,871, a novel farnesyltransferase inhibitor, blocks Ras farnesylation in vivo in a farnesyl pyrophosphate-competitive manner. Mol Pharmacol. 1998 Jul;54(1):1-7. PubMed PMID: 9658183.