TargetMol

(-)-Irofulven

Product Code:
 
TAR-T24176
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T24176-5mg5mg£1,572.00
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TAR-T24176-50mg50mg£3,107.00
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Quantity:
TAR-T24176-100mg100mg£4,247.00
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This product comes from: United States.
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Further Information

Bioactivity:
Irofulven is an agent of DNA-damaging and antitumor. It is used for the treatment of advanced solid tumors, including prostate, ovarian, and pancreatic cancers.
CAS:
158440-71-2
Formula:
C15H18O3
Molecular Weight:
246.306
Purity:
0.98
SMILES:
CC1=C(CO)C2=C(C)C3(CC3)[C@@](C)(O)C(=O)C2=C1

References

1. Staake MD, Kashinatham A, McMorris TC, Estes LA, Kelner MJ. Hydroxyurea derivatives of irofulven with improved antitumor efficacy. Bioorg Med Chem Lett. 2016 Apr 1;26(7):1836-8. doi: 10.1016/j.bmcl.2016.02.028. Epub 2016 Feb 13. PubMed PMID: 26922141. 2. Tummala H, Kirwan M, Walne AJ, Hossain U, Jackson N, Pondarre C, Plagnol V, Vulliamy T, Dokal I. ERCC6L2 mutations link a distinct bone-marrow-failure syndrome to DNA repair and mitochondrial function. Am J Hum Genet. 2014 Feb 6;94(2):246-56. doi: 10.1016/j.ajhg.2014.01.007. PubMed PMID: 24507776; PubMed Central PMCID: PMC3928664. 3. Glatt H, Pietsch KE, Sturla SJ, Meinl W. Sulfotransferase-independent genotoxicity of illudin S and its acylfulvene derivatives in bacterial and mammalian cells. Arch Toxicol. 2014 Jan;88(1):161-9. doi: 10.1007/s00204-013-1097-2. Epub 2013 Jul 24. PubMed PMID: 23881331. 4. Yu X, Erzinger MM, Pietsch KE, Cervoni-Curet FN, Whang J, Niederhuber J, Sturla SJ. Up-regulation of human prostaglandin reductase 1 improves the efficacy of hydroxymethylacylfulvene, an antitumor chemotherapeutic agent. J Pharmacol Exp Ther. 2012 Nov;343(2):426-33. doi: 10.1124/jpet.112.195768. Epub 2012 Aug 15. PubMed PMID: 22895897; PubMed Central PMCID: PMC3477217.