TargetMol

Curcuphenol

Product Code:
 
TAR-T23919
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T23919-5mg5mg£850.00
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Further Information

Bioactivity:
Curcuphenol in concentrations in the range of 29-116 μg/ml inhibited cell proliferation and DNA replication and induced cell death in a dose-dependent manner.
CAS:
69301-27-5
Formula:
C15H22O
Molecular Weight:
218.34
Purity:
0.98
SMILES:
C[C@H](CCC=C(C)C)c1ccc(C)cc1O

References

1. Green JC, Pettus TR. An oxidative dearomatization-induced [5 + 2] cascade enabling the syntheses of ?-cedrene, ?-pipitzol, and sec-cedrenol. J Am Chem Soc. 2011 Feb 9;133(5):1603-8. doi: 10.1021/ja109925g. Epub 2010 Dec 31. PubMed PMID: 21194216. 2. Rodrigo G, Almanza GR, Cheng Y, Peng J, Hamann M, Duan RD, Akesson B. Antiproliferative effects of curcuphenol, a sesquiterpene phenol. Fitoterapia. 2010 Oct;81(7):762-6. doi: 10.1016/j.fitote.2010.04.001. Epub 2010 Apr 10. PubMed PMID: 20385210. 3. Gul W, Hammond NL, Yousaf M, Peng J, Holley A, Hamann MT. Chemical transformation and biological studies of marine sesquiterpene (S)-(+)-curcuphenol and its analogs. Biochim Biophys Acta. 2007 Nov;1770(11):1513-9. Epub 2007 Jul 24. PubMed PMID: 17804167; PubMed Central PMCID: PMC2266081. 4. Cichewicz RH, Clifford LJ, Lassen PR, Cao X, Freedman TB, Nafie LA, Deschamps JD, Kenyon VA, Flanary JR, Holman TR, Crews P. Stereochemical determination and bioactivity assessment of (S)-(+)-curcuphenol dimers isolated from the marine sponge Didiscus aceratus and synthesized through laccase biocatalysis. Bioorg Med Chem. 2005 Oct 1;13(19):5600-12. PubMed PMID: 16039133.